MLL-r Leukemia
نویسنده
چکیده
25 years ago the HTRX, HRX, ALL-1, MLL gene, now renamed to KMT2A, has been discovered at chromosome 11q23 and shown to be rearranged with two different genes, AF4 and ENL, due to balanced chromosomal translocations. These two chromosomal translocations discovered in the labs of Carlo Croce and Michael Cleary-were the starting point for a new field of research associated with acute leukemia [1,2].
منابع مشابه
CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements
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